GHRP-6 protocol · PepGuide

Check your units. The units in this table assume 2 mg/mL, but the guide's recommended mix makes 5 mg/mL. If you mix it that way, your units will be different. Use the calculator to get the right draw for your vial.

Standard

Weeks 1–2

5u

100 mcg · 2×/day

Expect strong hunger ~20–30 min after dosing. AM fasted + pre-bed.

Weeks 3–12

10u

200 mcg · 2–3×/day

Working dose. ~1 mcg/kg saturates the GH response; more mainly adds cortisol/prolactin.

Off

4 weeks

Prevents ghrelin-receptor downregulation.

Phase	How often	Dose	Units	Notes
Weeks 1–2	2×/day	100 mcg	5u	Expect strong hunger ~20–30 min after dosing. AM fasted + pre-bed.
Weeks 3–12	2–3×/day	200 mcg	10u	Working dose. ~1 mcg/kg saturates the GH response; more mainly adds cortisol/prolactin.
Off	4 weeks	–	–	Prevents ghrelin-receptor downregulation.

Units column is labelled "Units (2 mg/mL)" in the source.

Cycle & timing

Cycle: 8–12 weeks on / 4 weeks off.

Timing: Empty stomach, no food 30 min after. The hunger surge is the tell that it's working (and why it suits bulking).

Where: SubQ, abdomen. Rotate.

What to expect

Strong appetite and improved sleep early; recovery and body-composition gains over 8–12 weeks. Best in a GHRH + GHRP stack during a gaining phase.

How much to buy

For 12-wk @ 200 mcg × 2/day:

7

× 5mg vials

4

× 10mg vials

Men & women

Men: Men overshoot the IGF-1 ceiling more easily (aim mid-normal); high prolactin lowers libido and testosterone, switch to a cleaner option if it climbs.

Women: Women need more GH but get a bigger bump from ghrelin-types, though these raise prolactin, which can disrupt cycles/ovulation (watch for missed periods). Oral estrogen blunts IGF-1.

Dilution calculator

Set to the guide's typical mix for GHRP-6. Change anything to see where to draw.

Vial size

BAC water added

Dose you want

Draw to

4u

Volume

0.04 mL

Strength

5 mg/mL

Doses per vial

25

Assumes a U-100 insulin syringe (100 units = 1 mL). Double-check against the compound's page before you draw.

Recommended mixes

Vial	Water	Strength
5 mg	1 mL	5 mg/mL
10 mg	2 mL	5 mg/mL

5 mg: 1 unit = 0.05 mg (50 mcg)

Storage

PowderFreeze-dried: -4°F.
MixedReconstituted: 36–46°F, up to 6 weeks.

Don't use if: Active malignancy of any kind (GH/IGF-1 can promote tumor growth) · Severe diabetic retinopathy · Acute critical illness (per somatropin label) · Pregnancy and lactation

Stop if you notice

Fasting glucose rises >20 mg/dL above baseline
IGF-1 above upper limit of normal for age
Uncontrolled appetite-driven weight gain
New persistent joint pain, carpal tunnel, or vision changes

Side effects

Pronounced hunger, flushing/warmth, water retention, mild cortisol/prolactin bump. Hunger fades with continued use.

Drug interactions

Glucocorticoids: blunt GH response. Insulin / antidiabetics: GH + appetite worsen glycemic control, monitor closely. Levothyroxine: GH lowers free T4, recheck TSH/fT4 quarterly. Oral estrogens: blunt GH-stimulated IGF-1.

Labs

IGF-1 (baseline + Week 8 + end). Fasting glucose / HbA1c (baseline + end), especially given appetite effect. Prolactin if symptomatic. Age-appropriate cancer screening before starting. Out of range? IGF-1 above your age range = too much growth signal (feeds hidden cancer, enlarges organs) → drop the dose; rising glucose/HbA1c = sugar creeping up.

What these labs mean →

Warnings

Strong appetite stimulation, can drive unwanted weight gain, poor glycemic control and insulin resistance with sustained use. Cortisol and prolactin elevation (similar to GHRP-2). Fluid retention, carpal tunnel, joint pain with extended use. IGF-1 elevation: theoretical malignancy promotion beyond physiological ranges. Requires off cycles to prevent receptor desensitization.

Patient education

Expect strong hunger, plan meals or it can sabotage a cut. Keep doses near the saturating range; more isn't better. Fasted dosing; protect sleep. Not for use during active malignancy or pregnancy; report new lumps or vision changes.

These apply on top of the universal safety rules.

Pairs well with

CJC-1295 (No DAC) / Sermorelin

GHRH + GHRP synergy

CJC-1295 (No DAC) Sermorelin

Ipamorelin

if appetite is unwanted

Ipamorelin

Wolverine Blend

recovery

Wolverine Blend

Avoid with

Active malignancy

Severe insulin resistance

Cutting phases

appetite

Elevated baseline prolactin

Can GHRP-6 + CJC-1295 (No DAC) share a syringe?

Mix freely: the classic GH pair. One GHRH primes the pituitary and one GHRP triggers a bigger pulse. Same solvent, pre-bed, empty stomach.

What it does

Somatropin (HGH) is approved for growth-hormone deficiency and tesamorelin (Egrifta) for HIV lipodystrophy. Secretagogues like this one are off-label.

GHRP-6 is a GHS-R1a (ghrelin receptor) agonist that triggers a GH pulse and powerfully stimulates hunger. Mild cortisol and prolactin rise. Combined with a GHRH analog (Sermorelin/CJC) the GH release is far larger than either alone. The strong appetite makes it a bulking-phase tool and a less ideal choice when cutting.

Saturation

Plateaus ~1 mcg/kg.

References

researchdosing peptidedosages PubMed thepeptidereport Span 2000 Weissberger 1991

From the guide, page 36.