Semax protocol · PepGuide

Standard

10u

500 mcg · Daily AM

Russian standard for cognitive use. SubQ abdomen or thigh.

Higher

20u

1,000 mcg · Daily AM

Research-range. Some users split into AM + early afternoon doses.

Off

1–2 weeks

Tolerance prevention. 5-day-on / 2-day-off variant also community-standard.

Phase	How often	Dose	Units	Notes
Standard	Daily AM	500 mcg	10u	Russian standard for cognitive use. SubQ abdomen or thigh.
Higher	Daily AM	1,000 mcg	20u	Research-range. Some users split into AM + early afternoon doses.
Off	1–2 weeks	–	–	Tolerance prevention. 5-day-on / 2-day-off variant also community-standard.

See Semax (Intranasal) for the nasal-route page.

Cycle & timing

Cycle: 2–4 week blocks, 1–2 weeks off.

Timing: AM SubQ, stimulating; avoid afternoon/evening doses.

Where: SubQ abdomen, upper outer thigh, or back of upper arm. For intranasal route, see the Semax (Intranasal) page.

What to expect

Mental clarity and focus often within hours of first dose. Sustained cognitive enhancement builds over 2–4 weeks. Brief headache in days 1–3 is normal.

How much to buy

For 4-wk @ 1000 mcg × 7/wk:

6

× 5mg vials

3

× 10mg vials

Men & women

Unisex nootropic / neuroprotective, same protocol for men and women, no cycle effect. Avoid in pregnancy.

Dilution calculator

Set to the guide's typical mix for Semax. Change anything to see where to draw.

Vial size

BAC water added

Dose you want

Draw to

10u

Volume

0.10 mL

Strength

5 mg/mL

Doses per vial

10

Assumes a U-100 insulin syringe (100 units = 1 mL). Double-check against the compound's page before you draw.

Recommended mixes

Vial	Water	Strength
5 mg	1 mL	5 mg/mL
10 mg	2 mL	5 mg/mL

5 mg: 1 unit = 0.05 mg

Storage

PowderFreeze-dried: -4°F.
MixedReconstituted/solution: refrigerate, use within 30 days.

Don't use if: Active psychosis or mania · MAOI therapy (theoretical serotonergic interaction) · Pregnancy and lactation

Side effects

Headache (first 1–3 days, resolves). Irritability if stacked with stimulants.

Drug interactions

MAOIs: avoid. SSRIs/SNRIs: theoretical serotonergic risk, monitor for serotonin syndrome. Stimulants: additive activation, reduce dose if combined. Sedatives/benzodiazepines: Selank may augment GABA effects.

Labs

Compound-specific: CBC + CMP baseline; no compound-specific markers routinely required

What these labs mean →

Warnings

Approved in Russia / Ukraine / some CIS states, not FDA-approved. Quality varies between research-chemical and pharmaceutical-grade suppliers. Headache common in initial days (Semax), often responds to choline. PCAC RECOMMENDED it for the 503A bulks list, 8–5 (Jul 2026; advisory, non-binding; FDA rulemaking pending).

Patient education

Neuroactive compounds, effects are real and dosing matters. Don’t combine with prescription antidepressants without physician input. Russian clinical practice: 10–14 day courses, not continuous. Headache common in days 1–3; choline source (alpha-GPC, citicoline) helps.

These apply on top of the universal safety rules.

Pairs well with

Selank

anxiolytic + cognitive synergy

Selank

BPC-157

neurorepair

BPC-157

Alpha-GPC or Citicoline

choline source prevents headache

Avoid with

MAOIs

Active psychosis / mania

Can Semax + Selank share a syringe?

Can share a syringe. Both are water-based. Combine them if you dose on the same schedule and site.

What it does

Approved pharmaceutical in Russia and Ukraine – and stroke recovery. analog stimulating BDNF/NGF synthesis, upregulating serotonin/dopamine receptors, and activating PDGF for neuroprotection.

Evidence

Russian-approved (stroke/cognition); no Western RCT.

Approved drug

There is no FDA-approved cognitive enhancer, no drug is approved for boosting focus or memory in healthy people (stimulants are approved only for ADHD/narcolepsy). Semax’s Russian approval does not apply in the US.

References

researchdosing peptidedosages PubMed thepeptidereport

From the guide, page 85.