Semax + Selank protocol

Once daily, AM

SubQ, start

5u

250 mcg each · Daily AM

Ease in; assess headache/tolerance.

SubQ, working

10u

500 mcg each · Daily AM

Standard working dose (0.10 mL).

Intranasal

2–4 sprays

200–400 mcg each · Daily AM

1–2 sprays per nostril, alternating sides.

Off

2 weeks

Tolerance prevention between blocks.

Phase	How often	Dose	Units	Notes
SubQ, start	Daily AM	250 mcg each	5u	Ease in; assess headache/tolerance.
SubQ, working	Daily AM	500 mcg each	10u	Standard working dose (0.10 mL).
Intranasal	Daily AM	200–400 mcg each	2–4 sprays	1–2 sprays per nostril, alternating sides.
Off	2 weeks	–	–	Tolerance prevention between blocks.

Onset: Selank calm within ~20–30 min (intranasal); Semax clarity within hours; full cognitive effect builds over 2–4 weeks. A brief headache in days 1–3 is normal, a choline source (Alpha-GPC / Citicoline) helps.

Cycle & timing

Cycle: 4 weeks on / 2 weeks off.

Timing: Morning only, Semax is stimulating, so avoid afternoon/evening dosing.

Where: SubQ abdomen/thigh/upper arm (rotate), or intranasal (alternate nostrils each dose).

What to expect

Selank calm within ~20–30 min (intranasal); Semax clarity within hours; full cognitive effect builds over 2–4 weeks.

Men & women

Unisex nootropic pairing, no meaningful sex or cycle effect; same protocol for men and women. Avoid in pregnancy.

Dilution calculator

Set to the guide's typical mix for Semax + Selank. Change anything to see where to draw.

Vial size

BAC water added

Dose you want

Draw to

10u

Volume

0.10 mL

Strength

5 mg/mL

Doses per vial

10

Assumes a U-100 insulin syringe (100 units = 1 mL). Double-check against the compound's page before you draw.

Recommended mixes

Vial	Water	Strength
10 mg (5+5)	1 mL BAC water	5 mg/mL each
10 mg (5+5)	5 mL sterile saline	1 mg/mL each

10 mg (5+5): SubQ. 1 unit = 50 mcg of each

10 mg (5+5): Intranasal. 1 spray (100 µL) = 100 mcg of each

Storage

MixedSubQ (BAC): refrigerate, use within 30 days. Intranasal (saline): 36–46°F, use within 21 days.
Toss itDiscard if cloudy (intranasal).
SubQ (BAC): refrigerate, use within 30 days. Intranasal (saline): 36–46°F, use within 21 days; discard if cloudy. Use a calibrated nasal pump (100 µL/actuation).

Don't use if: MAOI use (theoretical serotonergic interaction, Selank) · Active psychosis or bipolar mania (Semax is stimulating) · Pregnancy and lactation · Hypersensitivity to either peptide

Stop if you notice

Headache persisting past the first few days despite a choline source
New anxiety, agitation, or mood destabilization
Any allergic reaction

Side effects

Headache days 1–3 (Semax, resolves with choline); mild relaxation (Selank); irritability if stacked with stimulants. Generally very well tolerated.

Drug interactions

MAOIs / serotonergic agents: theoretical interaction (Selank). CNS stimulants (caffeine, ADHD meds): additive overstimulation with Semax. No major systemic (CYP) drug interactions documented.

Labs

None routinely required, generally very well tolerated.

What these labs mean →

Warnings

Two-peptide nootropic blend, both components' cautions apply at once. Semax is stimulating, no afternoon/evening dosing (insomnia). Additive overstimulation / irritability with other stimulants. Russian-approved but no completed Western RCTs, evidence is limited; quality varies, request a COA.

Patient education

Morning dosing only, Semax is stimulating; a brief day 1–3 headache is normal and a choline source (Alpha-GPC / Citicoline) helps. Intranasal needs a calibrated pump (100 µL/actuation), discard if cloudy. Russian-approved (Semax: stroke/cognition; Selank: anxiety); not FDA-approved in the West. Request a COA.

These apply on top of the universal safety rules.

Pairs well with

BPC-157

neurorepair

BPC-157

GHK-Cu

neuroprotective

GHK-Cu

Alpha-GPC / Citicoline

choline, prevents the day 1–3 headache

L-Theanine

amplifies Selank calm

Can Semax + Selank + BPC-157 share a syringe?

Can share a syringe. Both are water-based. Combine them if you dose on the same schedule and site.

What it does

Both Russian-approved; no Western RCTs.

Semax modulates BDNF and dopaminergic/cholinergic tone (focus, neuroprotection); Selank modulates GABA/serotonergic tone and immune signalling (anxiolysis without sedation). Complementary, the calm offsets the stimulation.

SubQ unit map (@ 5 mg/mL each)

Draw	Volume	Each peptide
5u	0.05 mL	250 mcg
10u	0.10 mL	500 mcg
2–4 sprays	intranasal	200–400 mcg

Approved drug

No FDA-approved cognitive enhancer exists (the Semax side). For the anxiety side (Selank), approved options are SSRIs (sertraline, escitalopram), SNRIs and buspirone.