LC216 protocol · PepGuide

Standard

Weeks 1–4

100u

1 mL · Weekly

Start at 1 mL weekly to assess tolerance. AgelessRx standard onboarding.

Weeks 5+

100u

1 mL · 1–2×/week

Increase to 2 mL/week or 1 mL twice weekly once tolerated. Energy and fat-loss adjunct dose.

Off

2–4 weeks

Optional break between 12-week blocks.

Phase	How often	Dose	Units	Notes
Weeks 1–4	Weekly	1 mL	100u	Start at 1 mL weekly to assess tolerance. AgelessRx standard onboarding.
Weeks 5+	1–2×/week	1 mL	100u	Increase to 2 mL/week or 1 mL twice weekly once tolerated. Energy and fat-loss adjunct dose.
Off	2–4 weeks	–	–	Optional break between 12-week blocks.

Cycle & timing

Cycle: Ongoing 8–12 week blocks; reassess at 16–20 weeks.

Timing: IM weekly for weeks 1–4, then 1–2×/week (per the protocol table), anytime; typically AM.

Where: IM upper outer glute preferred; SubQ acceptable.

What to expect

Energy lift within 1–2 weeks; fat-loss adjunct effect over 8–12 weeks.

Men & women

Unisex lipolytic / carnitine blend, dose by protocol; no meaningful sex difference. Avoid in pregnancy.

Recommended mixes

Vial	Water	Strength
10 ml	Solution, no reconstitution needed	L-Carnitine 20 mg/mL; L-Arginine 20 mg/mL; Methionine 25 mg/mL; Inositol 50 mg/mL; Choline 50 mg/mL; B6 25 mg/mL; B5 25 mg/mL; B12 1 mg/mL

10 ml: 1 unit = 0.20 mg

Storage

MixedSolution: refrigerate 36–46°F. Use within 30 days. Protect from light.

Don't use if: Component allergies (B12, riboflavin, lecithin, choline, methionine, lidocaine) · Hypothyroid medication, separate by 4 hours · Severe hepatic impairment (choline metabolism) · Pregnancy and lactation, specific compounding required · Bleeding disorders or anticoagulants (relative), bruising risk

Side effects

Garlic taste (methionine), flushing (niacin family), injection-site sting.

Drug interactions

Warfarin: L-carnitine and choline blends can potentiate, monitor INR if combining; Levothyroxine: separate by 4 hours, choline/B-vitamins affect absorption; Anticoagulants / antiplatelets (DOACs, aspirin, clopidogrel): bruising risk with phosphatidylcholine; Insulin / antidiabetics: B-complex may shift glucose, recheck log if dosing changes; Methotrexate, trimethoprim, phenytoin: deplete folate / B12; coordinate with prescriber; Lidocaine blends (LC526): avoid other caines same session, additive cardiac effects; Stimulants / phentermine: additive CV load with high-dose lipotropics, monitor BP/HR

Labs

Compound-specific: CBC + CMP baseline; no compound-specific markers routinely required; Baseline B12, folate, MMA, homocysteine (methylation markers); TSH at baseline (B12 deficiency masks hypothyroidism); Liver enzymes (choline metabolism); Hematocrit (B12 raises RBC, polycythemia risk in some)

What these labs mean →

Warnings

Compounded products, composition varies; request the pharmacy’s COA; B12 (cyanocobalamin) contains cobalt, allergy possible; Methionine elevates homocysteine in some individuals; L-Carnitine: TMAO conversion concern in CV disease (controversial, baseline lipids); Injection-site reactions common with phosphatidylcholine

Patient education

Fishy odor from choline/L-carnitine is normal, not allergic; Inject slowly to reduce stinging; Don’t use with warfarin without physician guidance (potentiation risk); Request exact ingredient list and concentrations from your compounder

These apply on top of the universal safety rules.

Pairs well with

GLP-1s

fat-loss adjunct

L-Carnitine standalone

additive

L-Carnitine

Avoid with

Sulfa allergy

theoretical methionine

Can LC216 + L-Carnitine share a syringe?

Can share a syringe. Both are water-based. Combine them if you dose on the same schedule and site.

Changes from the guide

The guide contradicted itself or had a slip here, so this page differs from the PDF:

Timing said 3×/week, but the protocol table says weekly, then 1–2×/week. Timing now follows the table.

What it does

Lipo-B, extended lipotropic: MIC + L-Carnitine + L-Arginine + B6 + B5 + B12. Methionine + Choline + Inositol: hepatic VLDL export. L-Carnitine: mitochondrial fat oxidation. L-Arginine: NO precursor.

References

peptidedosages PubMed thepeptidereport

From the guide, page 55.